Abstract
Hearts from control (RB) and cardiomyopathic (14.6) Syrian hamsters, 250 to 300 days of age, were analyzed by quantitative microscopic techniques. Extra-cellular space (ECS) and volume fractions occupied by various cell components were measured. In addition, the intra-cellular membrane surface areas of mitochondria, sarcoplasmic reticulum (SR), and sarcolemma plus T-tubules were determined. Significant alterations in ECS, SR volume fraction and SR membrane surface area were observed in the myopathic hearts. All other parameters measured were not significantly changed. The possible correlation of altered morphology with biochemical changes seen in the myopathic heart is discussed.
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