Abstract

目的 利用动态对比增强功能CT评价孤立性肺结节(SPNs),并探讨该方法在肺部结节良恶性鉴别诊断中的临床价值.方法对80例患有无钙化的SPNs (直径≤30 mm)的患者进行动态增强CT扫描.评价SPNs的时间-密度曲线(T-DC)模式;记录其增强前密度值、增强峰值(PH)、SPN与主动脉PH值的比值(S/A)以及SPNs的强化模式;计算SPNs的灌注值.结果恶性、良性及炎性结节显示了不同的T-DC模式.恶性和炎性结节的PH (P<0.0001;P<0.0001)和S/A比值 (χ2=32.62,P<0.0001; χ2=15.46, P<0.0001)显著高于良性结节; 而恶性和炎性结节之间的PH (P=0.96)和S/A (χ2=0.35, P=0.55)差异则无显著性意义.炎性结节增强前密度低于恶性结节(P<0.05).恶性和炎性结节的灌注值均高于良性结节(P<0.001,P<0.01),而恶性结节与炎性结节灌注值之间的差异则无显著性意义(P=0.63).结论动态对比增强功能CT提供了SPNs血流模式的定量信息,并可用于无创性地诊断和评价孤立性肺结节。

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