Abstract
We have previously reported that the folic-acid deficient chick exhibits only a very limited response to even excessively high doses of administered estrogen (Hertz, 1945). A similar impairment in estrogen response has been observed in the folic-acid-deficient monkey (Hertz, 1948). Moreover, the degree of response to injected estrogen as evidenced by increase in weight of the genital tract in the chick was shown to be quantitatively related to the amount of folic acid ingested. These observations have been confirmed by Kline and Dorfman (1948). Preliminary data have been previously presented indicating that the ingestion of a chemically unidentified, crude folic acid antagonist incorporated into a normal stock diet leads to a marked reduction in genital tract response to diethylstilbestrol in chicks (Hertz, 1948). Franklin et al. (1948) have reported similar observations. The present report is concerned with further quantitative studies on the inhibition of estrogen-induced tissue growth in the genital tr...
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