Abstract
The efficacy of chemotherapy is related, in large part, to the concentration of drug that reaches tumor sites. Doxorubicin (DOX) is a common anti-cancer drug that is also approved for use in liposomal form for the treatment of ovarian cancer. We recently developed a porphyrin-phospholipid (PoP)-liposome system that enables on demand release of DOX from liposomes using near infrared irradiation to improve DOX bioavailability. Owing to its intrinsic fluorescence, it is possible, and desirable, to quantify DOX concentration and distribution, preferably noninvasively. Here we quantified DOX distribution following light-triggered drug release in phantoms and an animal carcass using spatial frequency domain imaging. This study demonstrates the feasibility of non-invasive quantitative mapping of DOX distributions in target areas.
Highlights
One of the main challenges in the treatment of advanced ovarian cancer is the presence of disseminated microscopic residual nodules
To improve biodistribution and bioavailability, we recently developed porphyrin-phospholipid (PoP) liposomes that can be permeabilized on demand with near infrared (NIR) light, with excellent temporal and spatial control [7]
We choose 80 × 40 pixel region of interest (ROI) for the target area defined by the threshold determined by the intensity counts equal or above the 50% of the peak intensity
Summary
One of the main challenges in the treatment of advanced ovarian cancer is the presence of disseminated microscopic residual nodules. Incomplete surgical resection can lead to recurrence. Chemotherapy plays a major role and nanocarriers such as liposomes have been developed to enhance the biodistribution and anti-cancer efficacy of various drugs [4]. Liposomal doxorubicin is used in patients with recurrent ovarian carcinoma resistant to first-line platinum-based chemotherapy agents [5]. Drug delivery must overcome physiological barriers and release the nanocarrier contents in the tumor [6]. To improve biodistribution and bioavailability, we recently developed porphyrin-phospholipid (PoP) liposomes that can be permeabilized on demand with near infrared (NIR) light, with excellent temporal and spatial control [7]
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