Abstract
The effect of diazepam and nitrazepam in doses of 0.5, 1, 2.5, and 5 mg/kg on GABA-transaminase activity in the cerebellar cortex and hippocampus of rats was studied by a quantitative histochemical method. Inhibition of GABA-transaminase was found under the influence of both substances. The decrease in activity was particularly marked in the hippocampus after administration of diazepam. It is suggested that the changes observed are the result of inhibition of the enzyme and also of a decrease in the rate of GABA turnover.
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