Abstract
Quantitative HBsAg titers in relation to disease progression and serum markers of iron metabolism among chronic hepatitis B patients
Highlights
Chronic hepatitis B (CHB) infection is a common liver disorder with frequent progression to cirrhosis, and increased risk of hepatocellular carcinoma (HCC) alongside the high morbidity and mortality [1,2,3].Serum hepatitis B surface antigen (HBsAg) is a reliable biomarker of active hepatitis B virus (HBV) infection [4, International Journal of Hepatobiliary and Pancreatic Diseases, Vol 10, 2020
Serum Fe (78.2 ± 29.5 vs. 111.7 ± 36.8 μg/dL, p = 0.001), transferrin saturation [0.2 (0.1–0.5) vs. 0.3 (0.1–1.0) %, p < 0.001], and ferritin [27 (3.9–298) vs. 100 (31– 994) ng/mL, p < 0.001] levels were significantly lower in females than in males
Data on patient demographics were recorded, while measurements for quantitative HBsAg titers (IU/mL), hepatitis B e antigen (HBeAg) status, serum AST, ALT levels, HBV DNA levels, and serum iron parameters including serum Fe, total iron binding capacity (TIBC, μg/dL), transferrin saturation (%), and ferritin measurements were performed after enrolment in each patient
Summary
Chronic hepatitis B (CHB) infection is a common liver disorder with frequent progression to cirrhosis, and increased risk of hepatocellular carcinoma (HCC) alongside the high morbidity and mortality [1,2,3].Serum hepatitis B surface antigen (HBsAg) is a reliable biomarker of active hepatitis B virus (HBV) infection [4, International Journal of Hepatobiliary and Pancreatic Diseases, Vol 10, 2020. Chronic hepatitis B (CHB) infection is a common liver disorder with frequent progression to cirrhosis, and increased risk of hepatocellular carcinoma (HCC) alongside the high morbidity and mortality [1,2,3]. Following the recent standardization by automated quantitative assays, quantitative HBsAg titers have become increasingly used in stratification of the risk of disease progression and prediction of treatment response to antiviral therapy in patients with chronic HBV infection [7,8,9,10]. Many indices of iron metabolism such as hepatic iron, serum levels of iron, ferritin, and transferrin saturation have been used as diagnostic tools in detecting iron overload as a risk factor for liver fibrosis and disease progression [11,12,13,14]. Prevalence and clinical significance of disturbed iron metabolism in patients with HBV-related cirrhosis remain still inconclusive [3, 11, 12, 15]
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