Abstract
Received March 5, 1965 Because of its speed, accuracy, and sensitivity, gas chromatography offers advantages over other chromatographic methods for the determination of amino acids. Among derivatives which have been investigated are the trimethylsilyl Ntrimethylsilyl esters (h Hagen and Black, 1964; Cruickshank and Sheehan, 1964). Each of these derivatives has proved to be useful for gas-chromatographic separations, but none has been studied in sufficient detail to permit general analytical use. It was recognized that quantitative, reproducible derivative formation was an essential prerequisite for an accurate gas-chromatographic method, thus studies were made to investigate the organic reaction conditions necessary for quantitatively converting amino acids to volatile derivatives. This paper describes a general method for quantitative and
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