Abstract
Background. Histomorphic evaluation of dermal collagen and elastic fibres was analysed by image analysis technique. The quantification of dermal elements was performed in skin tissues, collected in horizontal and vertical directions from trunk region and discussed under the perspective of consequences of scar related complications. Materials and Method. Total number of 200 skin samples collected from 5 areas of trunk region were processed histologically and subjected to tissue-quant image analysis. Statistical analysis involving mean with SEM and paired t test by SPSS were employed to the percentage values obtained from image analysis. Result. Among the chosen 5 areas of trunk region, abdomen showed the statistically significant difference for both collagen and elastic content between horizontal and vertical orientations (P< 0.05), whereas upper back, presternal, and lateral chest areas showed significant difference (P< 0.05) only for collagen and groin only for elastic content. Conclusion. The differences in the distribution of dermal collagen and elastic fibres in 2 directions of the samples from the same areas might be attributed to final outcome of wound healing process by influencing the appearance and behaviour of scar related complications in the region of trunk.
Highlights
The mechanical qualities of skin provide a unique arrangement of strength and elasticity
Quantitative fraction of dermal collagen and elastic fibres was evaluated in 200 skin samples of 2 directions obtained from 5 areas of the trunk region from 20 cadavers
Upon analysis of content of dermal elements in the trunk region by image analysis method, it has been observed that the consistency of collagen remained more dominant in horizontally oriented sections than its vertical counterpart in all the areas tested
Summary
The mechanical qualities of skin provide a unique arrangement of strength and elasticity These functional qualities are achieved due to the predominate content of collagen network and to a lesser extent elastin and extracellular matrix substances in the underlying dermis [1]. Children have relatively thin skin, which progressively thickens until the fourth or fifth decade of life when it begins to thin This thinning is primarily a dermal change, with loss of elastic fibres, epithelial appendages, and ground substance [2]. The differences in the distribution of dermal collagen and elastic fibres in 2 directions of the samples from the same areas might be attributed to final outcome of wound healing process by influencing the appearance and behaviour of scar related complications in the region of trunk
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