Abstract
Although some investigators have shown a comparison of the neuroprotective effects of thiopental sodium and propofol, those comparisons were not quantitative. Therefore, in the present study, the neuroprotective effects of thiopental sodium, propofol, and halothane (for a control) were quantitatively evaluated. With use of a logistic regression curve, P50, which is the ischemic time and the duration of ischemic depolarization necessary for causing 50% neuronal damage in CA1 neurons, was estimated.
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