Quantitative evaluation of pancreatic fat deposition and iron deposition in patients with type 2 diabetes mellitus by 3.0T magnetic resonance IDEAL-IQ technique

Wenyan Zeng ,Peifan Liu ,Huajun Sun ,Niangtuo Zhuang ,Hongfang Liu ,Man Zhao ,Xingjie Wu

doi:10.3760/cma.j.issn.1007-1245.2019.13.004

Abstract

Objective To explore the clinical value of 3.0T magnetic resonance IDEAL-IQ technique in the quantitative evaluation of pancreatic fat deposition and iron deposition in patients with type 2 diabetes mellitus (T2DM) . Methods 3.0T MR examination (including IDEAL-IQ sequence) was performed on 32 newly diagnosed T2DM patients (T2DM group) and 15 healthy volunteers (control group). The fat content (FF) and iron content (R2* value) of the pancreas of each subject were measured by the IDEAL-IQ sequence. At the same time, fasting blood glucose (FBG) and fasting insulin (FINS) levels were measured in both groups; and the steady-state model insulin secretion index (HOMA-β) and steady-state model insulin resistance index (HOMA-IR) were calculated. The differences in pancreatic fat fraction (FF), R2* value, FBG, FINS, HOMA-β, and HOMA-IR between the T2DM group and the control group were compared. The correlations between FF and R2* values of pancreas in the T2DM group with HOMA-β and HOMA-IR were analyzed; and the correlation between pancreatic FF and R2* values in the T2DM group was analyzed. Results There were statistical differences in FBG, FNIS, HOMA-β, and HOMA-IR between the T2DM group and the control group (all P<0.05). The FBG, FNIS, and HOMA-IR were higher and the HOMA-β was lower in the T2DM group than in the control group. The pancreatic fat content (FF) and R2* values in the T2DM group were positively correlated with HOMA-IR (r=0.469, P=0.008; r=0.423, P=0.003), and negatively correlated with HOMA-β (r =-0.595, P=0.001; r =-0.478, P=0.001). There was a moderate positive correlation between pancreatic fat content (FF value) and iron content (R2* value) in the T2DM group (r=0.508, P=0.001). Conclusion 3.0T MR IDEAI-IQ technology can quantitatively analyze the fat and iron deposition in pancreas of patients with T2DM, which has certain guiding value for the assessment of the conditions of T2DM and the choices of treatment plan. Key words: Type 2 diabetes mellitus; IDEAL-IQ; Pancreatic fat content; Pancreatic iron content

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