Quantitative evaluation of liver diseases using multi-PDF models

Abstract

We have proposed the triple Rayleigh probability density function (TR-PDF) model as the in vivo QUS method of liver fibrosis. Additionally, the double Nakagami probability density function (DN-PDF) model was proposed to evaluate the amount and distribution condition of fat droplets in the fatty-liver livers. The DN-PDF permitted to detect early and moderate fatty livers in previous ex vivo studies with over 15 MHz ultrasound. In our recent studies, we are examining clinical data to determine whether two multi-PDF models can evaluate each disease even at low frequencies. In this talk, the results of in vivo studies for liver fibrosis and fatty liver will be introduced.We have proposed the triple Rayleigh probability density function (TR-PDF) model as the in vivo QUS method of liver fibrosis. Additionally, the double Nakagami probability density function (DN-PDF) model was proposed to evaluate the amount and distribution condition of fat droplets in the fatty-liver livers. The DN-PDF permitted to detect early and moderate fatty livers in previous ex vivo studies with over 15 MHz ultrasound. In our recent studies, we are examining clinical data to determine whether two multi-PDF models can evaluate each disease even at low frequencies. In this talk, the results of in vivo studies for liver fibrosis and fatty liver will be introduced.