Quantitative Evaluation of Chinese Herb Medicine in the Treatment of Sialorrhea and Frequent Nighttime Urination in Patients with Parkinson’s Disease

Chuanhe Sun,Dandan Wang,Weidong Pan,Weilong Liao,Penglin Gao,Te Liu,Wenfei Jiang

doi:10.1155/2017/3045260

Abstract

Aims. To evaluate the efficacy of Lian-Se formula (LSF), one Chinese herb formulation for treating sialorrhea and frequent overnight urination in patients with Parkinson's disease (PD). Methods. 96 PD patients suffering from sialorrhea and/or frequent nighttime urination were divided into two groups: an LSF group (n = 48) treated with LSF for 6 weeks and a placebo group (n = 48) treated with a placebo formula whose appearance and taste were the same as LSF for 6 weeks. All patients were treated by standard antiparkinsonism medicine according to the PD guideline of China. The changes of the quantity of saliva (QS) (mL), frequency of nighttime urination (FNU) and early sleep activity (ESA), and nocturnal activity (NA) by analyzing actigraphic records as the primary results and the total score of unified Parkinson's disease rating scale (UPDRS) and the Epworth Sleepiness Scale (ESS) as the secondary results were used to evaluate the clinical efficacy in both groups. Results. There were no significant differences in the baseline values of QS, FNU, NA, ESA, UPDRS total score, and ESS between the two groups. At the end of week 6, the QS, FNU, NA, and ESA in the LSF group showed superior results to those of the placebo group with no differences in the total UPDRS score between the two groups during the investigation. The ESS was significantly improved at the end of week 6 compared with the baseline and the placebo group. Laboratory test results indicated there were no side effects in either group. Conclusion. The findings of LSF treatment have clear clinical effects in patients with sialorrhea and frequent overnight urination. LSF thus appears to be a potential choice as an additional drug that can improve the sialorrhea and frequent overnight urination symptoms of PD patients.

Highlights

Parkinson’s disease (PD), traditionally, was clinically defined as a fundamental motor disorder that included involuntary tremulous motion with lessened voluntary muscular power and abnormal postures [1]
96 PD patients suffering from sialorrhea and/or frequent nighttime urination were divided into two groups: an Lian-Se formula (LSF) group (n = 48) treated with LSF for 6 weeks and a placebo group (n = 48) treated with a placebo formula whose appearance and taste were the same as LSF for 6 weeks
There were no significant differences in the baseline values of quantity of saliva (QS), frequency of nighttime urination (FNU), nocturnal activity (NA), early sleep activity (ESA), unified Parkinson’s disease rating scale (UPDRS) total score, and Epworth Sleepiness Scale (ESS) between the two groups

Summary

Introduction

Parkinson’s disease (PD), traditionally, was clinically defined as a fundamental motor disorder that included involuntary tremulous motion with lessened voluntary muscular power and abnormal postures [1]. Nonmotor symptoms (NMS) such as depression, pain, fatigue, bladder dysfunction (dysuria and frequent nighttime urination), sialorrhea, mood, constipation, and sleep disorders and even autonomic nerve disorders, cognitive decline, and delusions are clearly noted by neurological researchers from clinical investigations [2]. The symptoms of frequent nighttime urination and sialorrhea may influence motor symptoms and lead to the development of other NMS such as insomnia, mood disturbances, and depression in PD patients and, sometimes, may disrupt the quality of life to a greater extent than motor disorders. Traditional Chinese medicines (TCM) ameliorate various symptoms, aging-related symptoms [3], and are likely to be beneficial for chronic diseases such as PD. Both frequent nighttime urination and sialorrhea are explained in the theory of TCM

Methods

Results

Conclusion