Quantitative evaluation of cerebellar ataxia based on pathological patterns of the muscle activities

Abstract

Quantitative evaluation of cerebellar ataxia is crucial for precise evaluation of cerebellar diseases. In particular, it is essential to capture anomaly of the causal motor commands as well as the resultant movement for the ataxia. In this paper, we propose a new method to make a quantitative evaluation of the cerebellar ataxia based on EMG signals. As an experimental task, we asked subjects to perform step-tracking wrist movements with a manipulandum, and recorded wrist joint movements and muscle activities of four wrist prime movers with surface electrodes. The subjects included fourteen patients with cerebellar diseases and thirteen normal controls. We succeeded to extract two parameters from the EMG signals of the four wrist prime movers, which characterize the pathological patterns of muscle activities for the cerebellar ataxia, Total Co-contraction Level (TCL) and Directionality of Muscle Activity (DMA). We found that the two parameters were useful to characterize pathological patterns of muscle activities in cerebellar ataxia. Consequently, it is expected that our proposed method is useful not only in tracking condition of cerebellar patients but also in evaluating the effects of a treatment or neuro-rehabilitation aiming at the normalization of motor commands.