Abstract
Background: The objective of study was to investigate the major compounds of ginsenosides in Panax vietnamensis in its growing stages and their anti-proliferative activity in HeLa cells. Materials and Methods: The roots with different ages were analyzed by HPLC/MS. Anti-proliferation activity of P. Vietnamensis ginseng in HeLa cells was investigated using MTT assay. Results: Three main compounds of ginsenoside, Rb1, Rg1 and majonoside R2 were increased with the increasing of age. However, ginsenoside Rc, Re, Rd and Rg3 did not show any alteration with growing age. The major compound majonoside R2 was accumulated maximum in 5 years old ginseng. According to the data, the anti-proliferation activity was directly proportional to the growing ages of ginseng. The eleven years old ginseng showed maximum effect than the younger roots. This effect may be related to the concentration of ginsenosides or majonoside R2 content in P. Vietnamensis. Conclusion: The concentration of ginsenoside content in the roots of P. Vietnamensis is directly related to the growing ages. Overall, due to the higher concentration of ginsenoside in mature ginseng root, Panax vietnamensis ginseng can be used as an effective anti-proliferative drug.
Highlights
Ginseng has been found and known as a traditional herbal medicine a long time ago
We studied the anti-proliferative effect of Vietnamese ginseng (VG) in human cervical cancer cells (HeLa cells)
Re, Rg1, Rb1, Rc, Rd and Rg3 (20(S)-Rg3, 20(R)-Rg3) and majonoside R2 were investigated by high-performance liquid chromatography (HPLC)/MS
Summary
Ginseng has been found and known as a traditional herbal medicine a long time ago. There are several kinds of ginseng such as Panax ginseng C.A Meyer (Korean ginseng), Panax quinquefollius L. (American ginseng), Panax notoginseng and Panax vietnamensis (Vietnamese ginseng). Vietnamensis), commonly name as Vietnamese ginseng (VG), was found at Ngoc Linh Mountain in Vietnam in 1973. It is a special Panax species since it was discovered in the South while most of them are commonly found in the North (Le et al, 2014). Some studies have shown the significant effects of majonoside R2 on the central nervous system such as anti-stress, anti-depressive, and anxiolytic activities (Huong et al, 1995,1996,1997a,b,1998,2005). It was demonstrated as an effective anti-tumor and anti-cancer agent. We studied the anti-proliferative effect of VG in human cervical cancer cells (HeLa cells)
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