Abstract
Lipitame is a poly herbal formulation comprised of Terminalia arjuna, Terminalia belerica, Commiphora mukul and Phyllanthus emblica. The formulation is investigated for its analysis evaluation. Biomarkers of three herbs such as Terminalia arjuna, Terminalia belerica, and Phyllanthus emblica have been already cited to contain gallic acid, which was qualitatively and quantitatively estimated. In the present study rapid and inexpensive qualification methods for the quality control of Terminalia arjuna, Terminalia belerica, Commiphora mukul and Phyllanthus emblica on thin layer chromatography (TLC) were developed and validated. The solvent system used was toluene:ethyl acetate:formic acid:methanol (12:9:4:0.5). The scanning of plate was performed linearly at 273 nm (absorption) by use of a TLC Scanner III CAMAG with a deuterium source, and the area of spots corresponding to Gallic acid standard was integrated. It was found that gallic acid has been found in the Lipitame tablets on HPTLC densitometry assessment compared with authentic gallic acid reference standard.
Highlights
Controlled hyperglycemia has been cited as a primary cause of diabetic complications
The present standardization under taken reveal compliance with all the physic-chemical and analytical procedures, it is concluded that Lipitame tablets is well standardized product at the base line parameters
As Lipitame consists of Terminalia arjuna, Terminalia belerica, Commiphora mukul and Phyllanthus emblica and where as all the three Terminalia arjuna, Terminalia belerica and Phyllanthus emblica contains gallic acid, in the quantitative estimation gallic acid is well represented in different chromatogram
Summary
Controlled hyperglycemia has been cited as a primary cause of diabetic complications. Because there has been no effective and inexpensive therapeutic option to control glycemic or lipidemic levels in diabetic patients; these patients often suffer severe complications, including nephropathy, retinopathy, neuropathy and atherosclerosis. The high oxidant activity in diabetics coupled with dyslipidemia can lead to the formation of advanced glycation endproducts (AGEs). The presence of AGEs is associated with the formation of arterial atheromas and to the development of atherosclerosis. These complications can be mitigated in part by certain antioxidants, including superoxide dismutase, catalase and gluathione. Blocking the oxidative action of glucose responsible for diabetic vascular dysfunction has been validated as one approach to reduce the occurrence of diabetic complications. Antioxidants (such as vitamin E, vitamin C and alpha lipoic acid) and antiplatelet agents (such as aspirin and ticlopidine) are being tested to determine their efficacy against the progression of certain diabetic complications, such as non-proliferative diabetic retinopathy
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