Abstract
In Indian Ayurvedic system of medicine the leaf of Ghritkumari has been extensively used as a cathartic agent to treat severe stomach constipation. The aloe vera plant is used as food supplement and also used in cosmetic products to treat different skin problems. In order to develop reliable quality control marker to check its potential toxicity and carcinogenic activity and to check the commercial samples of Aloe vera for authenticity and purity, UV Spectroscopy analysis has been done. It has been found that aloin is present in a few commercial samples. HPLC, Infra-Red and thin layer chromatography methods have been reported for aloin determination in commercial samples. Therefore, UV Spectrophotometric method was developed for determination of aloin in commercial formulations.
Highlights
It is an important medicinal leaf of plant of Aloe barbadensis miller, known as curacao aloes, belonging to family liliaceae
HPLC, UV Spectroscopy, Infra-Red and thin layer chromatography methods have been reported for aloin determination
Aloin is used in various cosmetic products, used to treat acne, sunburns, itchy rash, psoriasis and oral submucous fibrosis
Summary
It is an important medicinal leaf of plant of Aloe barbadensis miller, known as curacao aloes, belonging to family liliaceae. Aloe vera contains varieties of chemical constituents from which anthraquinone glycoside is major constituent. Aloin is the principle active constituent of aloe vera, which contain mixture of glycosides. Aloin an active compound has laxative, anti-inflammatory and anti-cancer effect. Aloe vera is used both internally and externally for curing various ailments. In order to develop reliable quality control marker to check its potential toxicity and carcinogenic activity and to check the commercial samples of Aloe vera for authenticity and purity is essential. International aloe science council (IASC) has developed a set of identify, purity and quality standards for aloin containing products certified by IASC are prepared in manner to Figure 1: Structure of Aloin. Mechanism of action of aloin Effect on inflammation: Aloin, dose dependently inhibit inducible nitric oxide synthase mRNA expression and nitric oxide production. Nutrients in aloe vera a) Vitamin: A, B, C & E, M, b) Choline: Helps metabolism, c) Minerals: Calcium, Phosphorus, Potassium, Iron, Sodium, Chlorine, Zinc, d) Mono and Polysaccharides: Aldopentose, Cellulose, Glucose, L-rhamnose, Mannose, e) Fatty acids: cures Burns and wounds, f) Salicylic Acid: Anti-Bacterial, g) Amino Acid: Body needs 22 amino acids, out of 20 amino acids are provided by Aloe Vera, h) Lignin: A strong ability to penetrate human skin, i) Saponins: Work saponifying agent and antiseptic, j) Enzymes: Phosphatase-Amylase, k) Bradykinase: Immune building, Catalase prevents accumulating of water in system, l) Cellulase: Cellulose digestion, Creatine, m) Phosphokinase: muscular enzyme n) Lipase: digestion, Nucleotidase, Alkaline phosphate, o) Protease: hydrolyses proteins into their constitute elements
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