Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging for the Analysis of Microvascular Permeability in Peritumor Brain Edema of Fibrous Meningiomas

Abstract

Introduction: This study aims to analyze the permeability of intra- and peri-meningiomas regions and compare the microvascular permeability between peritumoral brain edema (PTBE) and non-PTBE using DCE-MRI. Methods: This was a retrospective of patients with meningioma who underwent surgery. The patients were grouped as PTBE and non-PTBE. The DCE-MRI quantitative parameters, including volume transfer constant (K^trans), rate constant (K_ep), extracellular volume (V_e), and mean plasma volume (V_p), obtained using the extended Tofts-Kety 2-compartment model. Logistic regression analysis was conducted to explore the risk factor of PTBE. Results: Sixty-three patients, diagnosed as fibrous meningioma, were included in this study. They were 17 males and 46 females, aged from 32 to 88 years old. K_ep and V_p were significantly lower in patients with PTBE compared with those without (K_ep: 0.1852 ± 0.0369 vs. 0.5087 ± 0.1590, p = 0.010; V_p: 0.0090 ± 0.0020 vs. 0.0521 ± 0.0262, p = 0.007), while there were no differences regarding K^trans and V_e (both p > 0.05). The multivariable analysis showed that tumor size ≥10 cm³ (OR = 4.457, 95% CI: 1.322–15.031, p = 0.016) and V_p (OR = 0.572, 95%CI: 0.333–0.981, p = 0.044) were independently associated with PTBE in patients with meningiomas. Conclusion: DCE-magnetic resonance imaging·Meningioma·Blood vessel MRI can be used to quantify the microvascular permeability of PTBE in patients with meningioma.