Abstract
A sensitive and specific gas chromatographic method, using teh nitrogen— phosphorus detector for the detection and determination of oxyphenbutanzone extracted from plasma is described. The method involves extraction and back-extraction steps followed by derivatization of both oxyphenbutazone and the internal standard wih trifluoroacetic anhydride. The procedure permits the rapid and specific routine with trifluoroacetic anhydride. The procedure permits the rapid and specific routine determination of oxyphenbutazone in plasma with a detection limit of 0.5 μg/ml. The procedure is linear over the range of concentrations encountered after administration of a single oral therapeutic dose. No interference from the biological matrix is apparent. The suitability of the method for the analysis of biological samples was tested by studying the variation with time of oxphenbutazone plasma concentrations in normal human volunteers over a period of several biological half-lives.
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