Abstract
Since the demonstration of the potentially carcinogenic risk in workers using benzidine and o-tolidine, the use of these substances in laboratories has been limited. As a consequence of this there is a need for replacing these substances in, for example, the determination of plasma hemoglobin concentration. We have tested dicarboxidine, y,y’-(4,4’-diamino-3,3’-biphenylenedioxy)dibutyric acid dihydrochloride, which AB Kabi, Sweden has manufactured as a chromogenic reagent for quantitative determination of the hemoglobin concentration in plasma, instead of benzidine in the peroxidase reaction modified by Bing and Baker [ 11. This substance is considered much less carcinogenic than benzidine [2].
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