Abstract
Metronidazole, or 1-(-hydroxyethyl)-2-methyl-5-nitroimidazole, is an antiprotozoal and antimicrobial drug possessing a broad spectrum of activity with respect to Protozoa as well as spore-forming and nonspore-forming obligate anaerobes [1]. The possibility of determining this drug by capillary band electrophoresis combining a number of advantages (high speed, simple sampling, small consumption of reagents, high separation efficiency, and simple equipment) [2] was recently demonstrated by Jin et al. [3]. The band of metronidazole was detected by ammetry. This technique is rarely used in laboratory practice, since most commercially available systems are equipped with UV sources and photometric detectors. This study was aimed at developing a procedure for the analysis of metronidazole using capillary band electrophoresis with UV detection. Rapid, accurate, and simple analytical technique would increase the precision of clinical analyses and improve the drug quality monitoring.
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