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Abstract
Antioxidants in the body are in balance, and form a network that protects living organisms against oxidative stress. To prove this hypothesis, we developed suitable methods for assessing the amount of antioxidants and their antioxidant activity in the chickens’ plasma, which enable us to explain the overall anti-oxidant status of the animals during the controlled industrial raise. The effects of exogenous coenzyme Q10, and α-lipoic acid on the reduction of oxidative stress in the animal body were assessed. The physical and the health conditions of chickens during the raising period of 40 days were followed. The benefits of additives were estimated through the measured concentrations of selected low molecular weight antioxi-dants (coenzyme Q10, α-lipoic acid, α-tocopherol, lutein and zeaxathin) and antioxidant enzymes (super-oxide dismutase, glutathione reductase), cholesterol and glucose in plasma and measurements of total antioxidant capacity. Quantitative analyses of selected substances were done with different chromatographic, spectroscopic and electrometric methods. The addition of antioxidants has positive effects on the acts of antioxidant network.
Highlights
The oxygen is a highly reactive molecule ready to damage living organisms [1,2]
Biological antioxidants may be classified into several defense groups; enzymes, low molecular weight compounds (LMWA) with antioxidant activities based on a chain of chemical reactions, for instance glutathione, vitamin C, vitamin E, α-lipoic acid (ALA), coenzyme Q10 (CoQ10), urea etc., and the group of widespread natural plant pigments which protect biological samples mostly against 1O2—mediated damages by physical quenching
In the second part of our work-analytical results presented in this paper, we evaluated the effects of CoQ10 and Alfa lipoic acid (ALA) on a minimization of the oxidative stress during the raise
Summary
The oxygen is a highly reactive molecule ready to damage living organisms [1,2]. In order to safely and effectively consume oxygen, organisms raise a complex network of enzymes, metabolites and molecules with antioxidant activities which prevent oxidative damage of cellular components. Biological antioxidants may be classified into several defense groups; enzymes (catalase, peroxidase and superoxide dismutase), low molecular weight compounds (LMWA) with antioxidant activities based on a chain of chemical reactions, for instance glutathione, vitamin C, vitamin E, α-lipoic acid (ALA), coenzyme Q10 (CoQ10), urea etc., and the group of widespread natural plant pigments which protect biological samples mostly against 1O2—mediated damages by physical quenching. Such substances are carotenoids, for instance ß-carotene, lycopene, lutein and zeaxanthin. The amount of protection provided by any antioxidant depends on its standard potentials E0 (V), concentration, reactivity towards the particular reactive oxygen species, and the status of the antioxidants with which it may interacts (Table 1)
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