Quantitative Determination of Local Density of Iron Oxide Nanoparticles Used for Drug Targeting Employing Inverse Magnetomotive Ultrasound.

Abstract

Numerous medical applications make use of magnetic nanoparticles, which increase the demand for imaging procedures that are capable of visualizing this kind of particle. Magnetomotive ultrasound (MMUS) is an ultrasound-based imaging modality that can detect tissue, which is permeated by magnetic nanoparticles. However, currently, MMUS can only provide a qualitative mapping of the particle density in the particle-loaded tissue. In this contribution, we present an enhanced MMUS procedure, which enables an estimation of the quantitative level of the local nanoparticle concentration in tissue. The introduced modality involves an adjustment of simulated data to measurement data. To generate these simulated data, the physical processes that arise during the MMUS imaging procedure have to be emulated which can be a computing-intensive proceeding. Since this considerable calculation effort may handicap clinical applications, we further present an efficient approach to calculate the decisive physical quantities and a suitable way to adjust these simulated quantities to the measurement data with only moderate computational effort. For this purpose, we use the result data of a conventional MMUS measurement and the knowledge on the magnetic field quantities and on the mechanical parameters describing the biological tissue, namely, the density, the longitudinal wave velocity, and the shear wave velocity. Experiments on tissue-mimicking phantoms demonstrate that the presented technique can indeed be utilized to determine the local nanoparticle concentration in tissue quantitatively in the correct order of magnitude. By investigating test phantoms of simple geometry, the mean particle concentration of the particle-laden area could be determined with less than 22% deviation to the nominal value.