Abstract
Abstract A method for quantitatively determining griseofulvin and griseofulvin-4′-alcohol in plasma was developed employing measurement of fluorescence directly on thin layer chromatograms. Chromatograms of plasma extracts were mechanically scanned with a modified Photovolt TLC Densitometer. The areas under the peaks produced by the scan were found to be linear with the amount of fluorescent material on the spots within a useful range. The errors incurred in the assay were 3.2 for the determination of griseofulvin and 4.7 for griseofulvin-4′-alcohol. The results of the TLC fluorimetric assay and the spectrophotofluorometric assay on plasma samples following oral doses of griseofulvin to rabbtis were in good agreement.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
