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Abstract
A persistent problem in the clinical management of primary melanoma is the detection of cryptic foci of metastatic melanoma. A specific chemical assay for tyrosinase or for one or more of the intermediates in the tyrosine-to-melanin metabolic pathway would be of value in estimating the degree of dissemination of the tumor. Such a test would prevent mutilating surgery or the use of a powerful and potentially injurious chemotherapeutic agent.
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