Abstract
Objective: Osteopontin (OPN) is a secreted phosphorylated glycoprotein that is implicated in proliferation and migration of several malignancies including hepatocellular carcinoma (HCC). In present study, human HCC specimens were collected and rat HCC model was chemical-induced to elucidate the expression significance of OPN in HCC progression. Methods: OPN expression was detected quantitatively by real-time reverse transcription polymerase chain reaction (RT-PCR). Male Sprague-Dawley rats were administrated diethylnitrosamine (DENA) to induce HCC and OPN expression was dynamically assessed. Results: In 69 cases of 103 HCC patients (67%) OPN was highexpressed in HCC tissues than that in adjacent non-tumor liver tissues and in 58 cases of these 69 cases more than 2-fold. OPN expression was significantly different between HCC and adjacent liver tissues (0.53±0.91 vs 0.11±0.28, P<0.001). OPN expression was gradually elevated in occurrence and development of rat HCC. Conclusion: OPN was highexpressed in human HCC and gradually elevated in rat HCC progression.
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