Abstract
An empirical model is proposed to detect the living cell fraction $\varPhi $ in a multi-mixed cell solution by micro electrical impedance spectroscopy (EIS) as $\varPhi = -1.46/\psi _{0} + 1.97$ . The living cell indicator $\psi _{0}$ is defined by a quotient of the extrema in the impedance imaginary parts of the detected cell solution’s medium, $Z_{{extmed}}$ , and referenced $Z_{{extmedref}}$ . The theoretical effectiveness of the model is examined by an electrochemical simulation. In addition, the sensor size versatility is discussed by a comparison experiment that reveals that the sensor size has little effect on the detection result. To support real-time detection, $Z_{{extmed}}$ and $Z_{{extmedref}}$ are replaced by the impedance of the cell solution, $Z_{{extm}}$ , and $Z_{{extmref}}$ . The versatility of real-time detection is discussed by a medium similarity coefficient $\eta (f)$ that is defined to explain the effect of replacement. The results reveal the feasibility of the replacement as $\eta > 95$ % in the injected current frequency range of $\psi _{0}$ by micro EIS.
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