Quantitative description of neuronal calcium dynamics in C. elegans’ thermoreception

Abstract

The dynamical mechanisms underlying thermoreception in the nematode C. elegans are studied with a mathematical model for the amphid finger-like ciliated (AFD) neurons. The equations, equipped with Arrhenius temperature factors, account for the worm’s thermotaxis when seeking environments at its cultivation temperature, and for the AFD’s calcium dynamics when exposed to both linearly ramping and oscillatory temperature stimuli. Calculations of the peak time for calcium responses during simulations of pulse-like temperature inputs are consistent with known behavioral time scales of C. elegans.