Abstract
Background : LVRC treatment is promising for patients with severe emphysema and collateral ventilation Objective : To identify QCT parameters associated with positive treatment outcome Methods : The CT scans from 72 patients were acquired at full inspiration before LVRC treatment. FEV 1 , RV, TLC and 6-minute walk test (6MWT) data was collected prior to and at 3 months after treatment. Various QCT parameters like emphysema percentage, heterogeneity score, vascular volumetry and low attenuation cluster (LAC) distributions were derived using Apollo imaging software (VIDA Diagnostics, Iowa, US). Independent predictors of outcome were identified through stepwise linear regression analysis. Results : The response rates satisfying Δ6MWT>=26m, ΔFEV 1 >=12% or ΔRV>=10% are 54.8%, 37.1% and 42% respectively. 70.8% (51/72) patients met at least one response criterion. Sicker patients with lower 6MWT, FEV 1 , and larger TLC at baseline tend to respond better. LAC distributions and vascular volumetry also constitute possible predicting factors of the response to treatment. Conclusion : QCT analysis of emphysema pattern might help improve patient selection for LVRC.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
