Abstract
Quantitative Cross-Polarization Optical Coherence Tomography Detection of Infiltrative Tumor Margin in a Rat Glioma Model: a Pilot Study
Highlights
Gliomas are the most common tumors (34%) of central nervous system in adult population [1, 2]
CP optical coherence tomography (OCT) imaging was performed on days 17–19 after the transplantation of glioma, when the tumor had formed and was visible on the brain surface (Figure 1 (b))
This study evaluates feasibility of Cross-polarization OCT (CP OCT) in delineating tumorous from non-tumorous tissue on rat C6-glioma model. 3D CP OCT images of both hemispheres (Figure 2 (b)) were acquired ex vivo after brain excision and its sagittal crosscutting (see Figure 2 (a)): right hemisphere — through the visual tumor center, left hemisphere — at the same plane as the right one for a more accurate comparison (Figure 1)
Summary
Gliomas are the most common tumors (34%) of central nervous system in adult population [1, 2]. Gross total tumor resection using conventional white-light microscopy can be achieved only in 25–30% of cases [7, 8, 12]. Assistive technologies such as fluorescence imaging and intraoperative MRI significantly enhance opportunities for the neurosurgeon and increase survival rate [13,14,15,16]. These methods have some limitations such as necessity of using contrast agents and lack of sufficient resolution. Optical bioimaging techniques such as multiphoton tomography [17] and optical coherence tomography (OCT) [18, 19] providing spatial resolutions in the range from 1 to 20 μm and requiring no external contrast look promising for a more precise detection of infiltrative tumor and can be considered as methods of optical biopsy
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