Abstract
Keratoconus is a highly prevalent corneal disorder characterized by progressive corneal thinning, steepening and irregular astigmatism. To date, pathophysiology of keratoconus development and progression remains debated. In this study, we retrospectively analysed topographic elevation maps from 3227 eyes of 3227 patients (969 keratoconus and 2258 normal eyes) to calculate anterior and posterior corneal surface area. We compared results from normal eyes and keratoconus eyes using the Mann–Whitney U test. The Kruskal–Wallis test was used to compare keratoconus stages according to the Amsler–Krumeich classification. Keratoconus eyes were shown to have statistically significantly larger corneal surface areas, measured at the central 4.0 mm and 8.0 mm, and total corneal diameter. However, no significant increase in corneal surface area was seen with increasing severity of keratoconus. We suggest that these results indicate redistribution, rather than increase, of the corneal surface area with keratoconus severity.
Highlights
Elevation data was obtained from topographic measurements using the Orbscan II, which have been shown to be repeatable[12]
Keratometry of eyes with keratoconus were steeper, but this difference decreased with the diameter of analysis
Our study demonstrates an increase in corneal surface area in eyes with keratoconus, the total corneal surface area remains constant with increasing keratoconus severity
Summary
The purpose of our study was to retrospectively compare corneal surface area calculated using raw topographic elevation data, in a large dataset of 2258 normal eyes from 2258 patients, and 969 keratoconus eyes from 969 patients
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