Abstract
Background LGE is widely used as a means to quantify scar or fibrotic tissue in patients suffering from cardiomyopathies. In clinical routine 2D data acquisition is most commonly practiced, albeit having the drawback of multiple breath-holds and long acquisition times. 3D acquisition can significantly reduce acquisition time. This leads to shortened scan time and a more efficient use of available MRI resources. So our purpose was to determine whether the quantification of myocardial fibrosis in patients with Fabry disease and hypertrophic cardiomyopathy (HCM) using a late gadolinium enhancement (LGE) single-breath-hold threedimensional (3D) inversion recovery magnetic resonance (MR) imaging sequence is comparable with a clinically established two-dimensional (2D) multi-breath-hold sequence.
Highlights
late gadolinium enhancement (LGE) is widely used as a means to quantify scar or fibrotic tissue in patients suffering from cardiomyopathies
Our purpose was to determine whether the quantification of myocardial fibrosis in patients with Fabry disease and hypertrophic cardiomyopathy (HCM) using a late gadolinium enhancement (LGE) single-breath-hold threedimensional (3D) inversion recovery magnetic resonance (MR) imaging sequence is comparable with a clinically established two-dimensional (2D) multi-breath-hold sequence
In patients with Fabry disease there was no significant differences in myocardial mass between 3D (100.7 g ± 30.8 g) and 2D acquisition(99.9 g ± 31.9 g; P = 0.55), as well as for fibrous tissue mass(3.9 g ± 6.4 g vs 4.0 ± 6.4 g; P = 0.89) and total fibrous percentage (3.4% ± 5.5% vs 3.4 ± 5.5; P = 0.89)
Summary
Quantitative comparison of 2D and 3D late gadolinium enhancement MR imaging for cardiomyopathies. Fabian Morsbach1*, Sonja Gordic, Robert Götti, Markus Niemann, Hatem Alkadhi, Gruner Christiane, Robert Manka. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. 16-19 January 2014
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