Abstract
Proteases in the gastric juice of normal dogs and cats with cinchophen-induced gastric ulcer were studied by disk electrophoresis, and ulceration in fasting animals was shown to be accompanied by considerable quantitative changes in the protease spectrum. A generalized reduction in the proteolytic fractions of the gastric juice in response to sham feeding of the dogs during ulcer formation was accompanied by a significant increase in fraction No. 6. Sham feeding of satiated dogs during ulcer formation revealed a significant increase in fractions Nos. 1 and 2. Changes in the protease spectrum of the gastric juice may be of ulcerogenic significance.
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