Abstract
Serious economic losses due to red seabream iridovirus (RSIV) infection have occurred in fingerlings and market-sized rock bream Oplegnathus fasciatus in Korea. Previously, it was demonstrated that fishes immunized with a live fish RNA virus following polyinosinic–polycytidylic acid [Poly(I:C), an inducer of interferon (IFN)] administration were protected from the viral infection [Poly(I:C) immunization with live virus]; however, rock bream administered Poly(I:C) were not protected from RSIV infection, although IFN was expressed well in rock bream that received Poly(I:C). In this study, we investigated kinetics of the RSIV in rock bream that did or did not receive Poly(I:C). No significant difference was observed in the mortality pattern due to RSIV infection regardless of Poly(I:C) administration, indicating that rock bream administered Poly(I:C) were not protected from RSIV infection. No significant difference was observed in the pattern of RSIV kinetics between the fishes that did or did not receive Poly(I:C). We would conclude that RSIV is resistant to IFN induction in rock bream.
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