Abstract
Previous studies assessing associations between matrix metalloproteinase 2 (MMP-2) polymorphisms and lung cancer risk reported conflicting results. A meta-analysis was therefore performed to derive a more precise estimation. Case-control studies assessing associations between MMP-2 C735T and C1306T polymorphisms and lung cancer risk were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. 7 studies with a total of 3,189 lung cancer cases and 3,013 controls were finally included into this meta-analysis. Overall, the MMP-2 C735T polymorphism was associated with lung cancer risk under the homozygote model (CC versus TT: OR =1.44, 95% CI = 1.03-2.02, I2 = 0%), while the MMP- 2 C1306T polymorphism also associated demonstrated links with all four models (all P values less than 0.05). Subgroup analyses by race suggested obvious associations between MMP-2 C735T and C1306T polymorphisms and lung cancer risk in Asians but not in Caucasians. There was no evidence for publication bias. Currently available evidence supports teh conclusion that MMP-2 C735T and C1306T polymorphisms influence susceptibility to lung cancer in Asians.
Highlights
Lung cancer is the most frequently occurring cancer and the leading cause of death from cancer worldly (Jemal et al, 2011)
The matrix metalloproteinase 2 (MMP-2) C735T polymorphism was associated with lung cancer risk under the homozygote model (CC versus TT: odds ratios (ORs) =1.44, 95% confidence intervals (CIs) = 1.03-2.02, I2 = 0%), while the MMP2 C1306T polymorphism associated demonstrated links with all four models
Meta-analysis results The outcome for the association between Matrix metalloproteinases (MMPs)-2
Summary
Lung cancer is the most frequently occurring cancer and the leading cause of death from cancer worldly (Jemal et al, 2011). Background: Previous studies assessing associations between matrix metalloproteinase 2 (MMP-2) polymorphisms and lung cancer risk reported conflicting results. Method: Case-control studies assessing associations between MMP-2 C735T and C1306T polymorphisms and lung cancer risk were included.
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