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Abstract
Serum HBV DNA levels were quantified simultaneously by slot-blot hybridization using digoxigenin-labeled probe (S) and by Abbott HBV DNA assay (A). Samples, 69, from 64 patients seropositive for hepatitis B e antigen (HBeAg) were included and the percentages of hepatocytes containing hepatitis B core antigen (HBcAg) were also compared. The extent of HBcAg staining was only moderately correlated with HBV DNA levels detected by either Abbott (R2 = 0.41; P < 0.01) or slot-blot hybridization (R2 = 0.33; P < 0.01) assays. On the other hand, HBV DNA concentrations assessed by either method were well correlated although the levels differed markedly (S = 3.0 × A1.31; R2 = 0.85; P < 0.01). These results indicated that digoxigenin-labeled probe can be used to quantify serum HBV DNA concentration, although a different range of levels was obtained when compared with Abbott HBV DNA assay.
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