Abstract
The assessment of myocardial perfusion by cardiac magnetic resonance (CMR) is increasingly used for non-invasive diagnosis of myocardial ischaemia. Perfusion CMR has a number of competitive advantages over other cardiac imaging modalities, including the possibility to perform quantitative analysis of stress-induced myocardial blood flow and to quantify myocardial perfusion reserve. Several methods for quantitative analysis have been described and extensively validated in preclinical and clinical models of myocardial ischaemia. Nevertheless, quantitative perfusion CMR analysis has, thus far, been restricted to the research arena. Its use in clinical implementation has not yet been the subject of major clinical studies. This review aims to discuss the evidence supporting the use of quantitative perfusion analysis and to discuss the open issues preventing an effective translation to clinical practice.
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