Abstract
To calculate ventilation: the lungs were segmented on the inhale and exhale phase of the 4DCT dataset. Once the lungs were appropriately segmented, a deformable image registration algorithm was used to link the lung voxel elements in the inhale phase to the exhale phase. Following spatial registration, corresponding Hounsfield Units were input into a density-change-based model for quantifying the local ventilation (Equation 1).
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