Quantitative assessment of interstitial implants

Abstract

Quantitative assessment of interstitial implants is proposed using volume versus dose curves and four well-defined dosimetric parameters. The volume versus dose curves, both differential and cumulative, provide quantitative data on the volumes of tissues irradiated to different doses. They also offer a qualitative assessment of the variations in dose delivery. The dose nonuniformity ratio (DNR) quantitatively determines the degree of dose nonuniformity specific to the implant configuration. The dose rate at which the DNR shows a minimum value, if selected as the treatment dose rate, gives an optimized dose distribution. The three volumetric irradiation indices are formulated with respect to a well-defined target volume. They offer quantitative data on the extent to which the implant delivers the prescribed dose to the target volume. These dosimetric parameters determine the degree of coverage of the target volume, dose homogeneity within the target volume, and irradiation of tissues outside the target volume. The method of quantitative assessment is demonstrated using, as examples, an ideal Ir-192 double-plane implant and an actual clinical Ir-192 double-plane breast implant.