Abstract
PURPOSE: Alteration in pulmonary vessel structure and function are highly prevalent in patient with chronic obstructive pulmonary disease (COPD). Pulmonary hypertension caused by vascular abnormalities is one of the factors associated with survival in COPD patients. Recently, it was reported these change observed in early stage of COPD. However, relationship of structural change and severity of COPD has not been assessed. We purposed to quantify cross-sectional area of small pulmonary vessels (CSA) and low attenuation area (LAA) in COPD using inspiratory and expiratory multi-detecter row CT (MDCT) scans and analyze the relationship between airflow limitation and these parameters.
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