Abstract
The metabolism of DMBA in vitro has been examined using liver homogenates from rats, mice, hamsters and guinea pigs. Estimation of the known end-products of DMBA metabolism has shown that transient increases in hepatic enzyme activities occur in rats and mice in the post-weaning period, which are probably due to dietary components first ingested at weaning. Differences in hepatic DMBA metabolism do not appear to account for the inability of the hydrocarbon to cause adrenal necrosis in adult mice, hamsters and guinea pigs.
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