Abstract
Abstract. The degree of hemolysis was evaluated by determination of serum lactic dehydrogenase activity (LDH) in 97 non‐selected cases with unoperated aortic valvular disease and 56 patients with Starr‐Edwards aortic ball valves. Significant hemolysis was uncommon in unoperated patients. Increased red blood cell destruction was found in the majority of patients with prosthetic valves and exceeded twice the normal in about 35% of the cases. When present, anemia was usually due to iron deficiency. The probable mechanisms of anemia in patients with prosthetic heart valves are discussed.
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