Quantitative and qualitative alterations of plasma clusterin, paraoxonase 1, myeloperoxidase and HDL’s apolipoproteins are aggravated by hyperglycemia in peripheral artery disease patients with diabetes

Abstract

Background and Aims: Peripheral artery disease (PAD), the atherosclerotic disorder that affects arteries of the lower limbs, has increasing incidence worldwide, the major risk factors being dyslipidemia and diabetes mellitus (DM). Some of the key players in the atheroma formation are dysfunctional high-density lipoproteins (HDL), whose components that contribute to PAD evolution are less known. We aimed to identify alterations of HDL constituents which associate with PAD aggravation.