Abstract
The synthesis of deuterium- and tritium-labeled analogs of 2,3-dinor-6-keto-prostaglandin F 1α and of 6,15-diketo-13,14-dihydro-2,3-dinor-prostaglandin F 1α is described. These analogs were used as internal standards in the assay of the corresponding unlabeled metabolites in human urine by stable isotope dilution and combined gas chromatography-mass spectrometry. In male subjects the 24-h urinary excretion of the two metabolites was found to be 719 ± 264 and 314 ± 115 ng, respectively. The method offers a noninvasive approach to the study of prostaglandin I 2 synthesis in man.
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