Abstract
To study in vivo effect of methylcobalamin (CH3-B12) on the peripheral nerve structures, rats with experimental diabetes induced by streptozotocin were administered with daily intramuscular injection of CH3-B12 (500μg/kg). Improved general conditions such as an increase in body weight or ameliorated glucose intolerance were observed in the diabetic rats treated continuously with CH3-B12 for 16 weeks.There were no definite morphometrical differences between the diabetic rats treated with CH3-B12 only for 8 weeks during the latter half of this experiment, and non-treated iabetic rats. However, the diabetic rats continuously treated with CH3-B12 for 16 weeks showed low incidence of degenerated nerve fibers and less reduction of myelinated nerve fiber density than those of npn-treated diabetic rats (p<0.01 and p<0.05).The reduction of myelinated nerve fibers predominantly of large diameter (5-8μ) were prevente in the treated diabetic rats in contrast with those of nontreated diabetic rats on the histograms of the diameter of myelinated nerve fibers.The results suggested that an early continuous treatment with CH3-B12 inhibited the evolution of peripheral nerve lesions in rats with experimental diabetes.
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Schedule a callMore From: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
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