Quantitative Analysis of Salivary TNF-α in Oral Lichen Planus Patients.

T Malarkodi,S Sathasivasubramanian

doi:10.1155/2015/283465

Abstract

Objective. The aim of this study was to quantitatively evaluate the salivary tumor necrosis factor-alpha (TNF-α) level in oral lichen planus patients and to compare the levels of TNF-α between saliva and serum of OLP and controls. Methods. Serum and whole saliva from 30 patients with active lesions of oral lichen planus (OLP) and 30 healthy persons were investigated for the presence of TNF-α by enzyme immunoassay. Student's independent t-test and two-sample binomial proportion test were used to calculate significance of the mean values of TNF-alpha in serum and saliva and to determine the proportions of the detected and nondetected samples in both groups. Results. Proportion of detection and the mean of detectability between saliva and serum of Group B show an almost equal value, which suggests that saliva can be a good alternate to serum to analyze TNF-α in oral lichen planus patients.

Highlights

Lichen planus (LP) is a chronic inflammatory mucocutaneous disease
Students’ independent t-test was used to compare the mean values of Group A and Group B (OLP) in Tables 1 and 2
The proportion of detectability of TNF-α in saliva of oral lichen planus (OLP) patients as shown in Table 3 and Figure 1 was high when compared to controls and was statistically significant with a P value of 0.02

Summary

Introduction

Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. It was first described by the British physician Erasmus Wilson in 1869. The clinical appearances of these lesions resembled lichens a primitive organism of symbiotic algae and fungi growing on rocks, designated as lichen planus [1]. This disease primarily affects the skin and mucosal surfaces including the oral cavity. It can involve other sites like the scalp and the nails [2]. WHO has grouped this condition under the “potentially malignant disorders” of the oral mucosa [4]

Methods

Results

Conclusion