Abstract
A fast, inexpensive and direct quantitative Fourier-Transform Infrared Spectroscopic method was established for rosuvastatin calcium for analysis in bulk and solid pharmaceutical dosage forms. Content of rosuvastatin calcium was directly analysed without any solvent extraction by this method. Absorption mode was used on KBr pallets for acquisition of Fourier-Transform Infrared spectra. The method was validated against prescribed parameters as per International Council for Harmonisation guidelines. Range of linearity range was found to be 5-20% w/w in KBr pellet method. Proposed method was successfully applied for the determination of rosuvastatin in solid pharmaceutical dosage forms (tablets). The results suggest that the method is precise, accurate and reproducible. Due to its simplicity, cost effectiveness and less time taking, this method can be employed for routine estimation of rosuvastatin calcium in solid dosage forms in pharmaceutical industry.
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