Abstract
Optical coherence tomography (OCT) provides not only morphological information but also information about layer-specific optical intensities, which may represent the underlying tissue properties. The purpose of this study is to quantitatively investigate the optical intensity of each retinal layers in central retinal artery occlusion (CRAO). Twenty-nine CRAO cases at acute phase and 33 normal controls were included. Macula-centered 3D OCT images were segmented with a fully-automated Iowa Reference Algorithm into 10 layers. Layer-specific mean intensities were determined and compared between the patient and control groups using multiple regression analysis while adjusting for age and optical intensity of the entire region. The optical intensities were higher in CRAO than in controls in layers spanning from the retinal ganglion cell layer to outer plexiform layer (standardized beta = 0.657 to 0.777, all p < 0.001), possibly due to ischemia. Optical intensities were lower at the photoreceptor, retinal pigment epithelium (RPE), and choroid layers (standardized beta = −0.412 to −0.611, all p < 0.01), possibly due to shadowing effects. Among the intraretinal layers, the inner nuclear layer was identified as the best indicator of CRAO. Our study provides in vivo information of the optical intensity changes in each retinal layer in CRAO patients.
Highlights
Optical coherence tomography (OCT) provides morphological information and information about layer-specific optical intensities, which may represent the underlying tissue properties
We quantitatively investigated the reflectivity, or optical intensity in each of 10 retinal layers identified in 3D-OCT images from patients with central retinal artery occlusion (CRAO) using a validated automatic computer algorithm and compared with the same measurements obtained from normal controls[18,19,20,21,22]
In this study, we quantitatively investigated the optical intensities in each segmented retinal layer detected from 3D-OCT for CRAO patients and normal controls
Summary
Optical coherence tomography (OCT) provides morphological information and information about layer-specific optical intensities, which may represent the underlying tissue properties. No thickness change of the photoreceptor/retinal pigment epithelium (RPE) layer was observed in either the acute or chronic phase[8]. Besides change of the retinal thickness, it was observed that the reflectivity increased in the inner retina and correspondingly decreased in the outer retina in the acute phase of CRAO. The reflectance of the retinal nerve fiber layer decreases compared to that of normal controls[16], and reflectance changes can be seen even before any thinning is detected[17] These results suggested that the optical intensities of intraretinal or subretinal spaces can be used as biomarkers and provide clues to the pathogenesis of retinal diseases
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