Quantitative analysis of PRAME for detection of minimal residual disease in leukemia.

Abstract

AbstractPreferentially expressed antigen of melanoma (PRAME) was first isolated using cDNA expression cloning techniques as a gene encoding a human melanoma antigen recognized by melanoma reactive cytotoxic T-cells (CTL) (1). This gene codes for a 509-amino-acid protein whose function has not yet been identified. PRAME is expressed in various types of cancer, including melanoma (97%), sarcoma (80%), small-cell lung cancer (70%), renal cell carcinoma (40%), and head and neck cancer (29%) (1,2). PRAME is also found in limited normal tissues, including endometrium and adrenal glands, and found highly expressed in testis.KeywordsAcute Lymphocytic LeukemiaChronic Myelogenous LeukemiaMinimal Residual DiseaseAcute Myelogenous LeukemiaPolymerase Chain Reaction CycleThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.