Abstract
In this data, non-pregnant women during the menstrual cycle, women with normal intrauterine pregnancy (IUP), and women with tubal ectopic pregnancy (EP) after informed consent were included. The serum levels of 17β-estradiol, progesterone, testosterone, beta-human chorionic gonadotropin, interleukin (IL)-1β, IL-4, IL-6, IL-7, IL-8, IL-10, tumor necrosis factor α (TNFα), and interferon-γ (IFN-γ), epidermal growth factor, the Chlamydia (C.) trachomatis IgG and HSP60 were analyzed. Receiver operating characteristic analysis was used to assess the diagnostic discrimination of tubal EP and gestational age-matched IUP. Our data show that C. trachomatis infection is associated with IL-8 levels, which had excellent discriminative validity in positively identifying tubal EP (concomitant with C. trachomatis infection) from IUP and non-pregnant conditions regardless of C. trachomatis infection.
Highlights
Quantitative analysis of hormones and inflammatory cytokines in Chlamydia trachomatis-infected women with tubal ectopic pregnancy and early intrauterine pregnancy
Receiver operating characteristic analysis was used to assess the diagnostic discrimination of tubal ectopic pregnancy (EP) and gestational age-matched intrauterine pregnancy (IUP)
Our data show that C. trachomatis infection is associated with IL-8 levels, which had excellent discriminative validity in positively identifying tubal EP from IUP and non-pregnant conditions regardless of C. trachomatis infection
Summary
Tables and figure Competitive RIA, human cytokine magnetic bead array and ELISA kits. 3. Receiver operating characteristic (ROC) curves were used to assess the specificity and sensitivity of the cytokine levels in response to C. trachomatis infection for discriminating tubal EP from IUP and non-pregnant conditions. The ROC analysis showed that the IL-8 level had excellent discriminative validity in positively identifying tubal EP (concomitant with C. trachomatis infection) from IUP and non-pregnant conditions regardless of C. trachomatis infection (Fig. 1). 4. There were no significant differences in IL-4, IL-6, IL-7, IL-8, TNFα, or IFN-γ levels among C. trachomatis-positive or negative women under pregnant and non-pregnant conditions (Table 2). 5. We found that individual measurements of serum EGF levels were strongly related to early pregnancy outcomes for women with tubal EP and IUP (Table 2)
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