Quantitative Analysis Of DEG/ENaC Subunits Interaction

Abstract

Members of the DEG/ENaC protein family are voltage-independent, amiloride-sensitive cation channels. This family includes acid sensing ion channels (ASICs), which are involved in sensory function, modulation of learning and memory in the nervous system. Another branch of the DEG/ENaC family includes epithelial sodium channels (ENaCs) that are key players in sodium transport across epithelia. ‘Classical’ ENaCs are formed by three different subunits named α, β and γ. A forth subunit, δ, has been found in humans and other primates.